Kratom Lords

  Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa ( Kratom ) leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity. Mitragyna speciosa (kratom) Alkaloids Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist. Mitragynine is the primary alkaloid in kratom, and is believed to be responsible for the majority of its effects. Roughly 66% of total alkaloid content found in Kratom leaf. Paynantheine: Indole alkaloid. Appears to be a smooth muscle relaxer, but there is limited research available and more needs to be done. 8.6% to 9% of total alkaloid contents in Kratom leaf. Second most abundant alkaloid. Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. < 1%" of total a...

Kratom’s two primary alkaloids — 7-hydroxymitragynine and mitragynine — are responsible for producing most of its many pharmacological effects. Alkaloids are organic compounds containing nitrogen, an extremely broad category that includes chemicals like ephedrine, caffeine, and morphine; 7-hydroxymitragynine is unique because it’s a derivative of mitragynine. Alkaloid concentrations can vary between kratom strains, but, on average, 7-hydroxymitragynine makes up only 2% of kratom’s alkaloid budget. For comparison, mitragynine comprises up to 66% of alkaloids in some Thai kratom strains. However, the concentrations alone don’t tell the whole picture, and even minimal 7-hydroxymitragynine concentrations play an important role in influencing kratom’s pharmacological effects. Where Does 7-hydroxymitragynine Come From? Kratom plants produce mitragynine as part of their natural life cycle. As the plants mature, mitragynine is converted to 7-hydroxymitragynine through oxidation, th...