Kratom Lords

  Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa ( Kratom ) leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity. Mitragyna speciosa (kratom) Alkaloids Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist. Mitragynine is the primary alkaloid in kratom, and is believed to be responsible for the majority of its effects. Roughly 66% of total alkaloid content found in Kratom leaf. Paynantheine: Indole alkaloid. Appears to be a smooth muscle relaxer, but there is limited research available and more needs to be done. 8.6% to 9% of total alkaloid contents in Kratom leaf. Second most abundant alkaloid. Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. < 1%" of total a...

WEST LAFAYETTE – The 2019 National Survey on Drug Use and Health reported that 14.5 million people ages 12 and older have alcohol use disorder, or AUD. This represents 5.3% of that population, according to the National Institute on Alcohol Abuse and Alcoholism. Arryn Blaine, a doctoral candidate in Purdue University’s College of Pharmacy, conducts research in Richard Van Rijn’s laboratory on compounds that may be able to treat alcohol use disorder. The compounds are based on alkaloids found in the kratom plant. (Purdue Research Foundation photo/Steve Martin) Researchers in Purdue University’s College of Pharmacy, the Purdue Institute for Drug Discovery and Washington University in St. Louis are synthesizing compounds to treat people affected by AUD. The research was published in the peer-reviewed journal Frontiers in Pharmacology. Richard Van Rijn, adjunct associate professor of medicinal chemistry and molecular pharmacology in Purdue’s College of Pharmacy, leads the r...