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Kratom Science: Latest Evidence on Safety and Regulation

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Kratom Science Update: Evidence-Based Facts The FDA has a long-standing bias against any dietary ingredient, botanical supplement, or dietary supplement that is not a chemical formulation subject to regulatory approval as a new drug. In 1994, Congress passed the Dietary Supplement Health and Education Act (DHEA) to reign in the FDA’s overregulation of dietary supplements FDA wanted banned on the premise they were highly addictive, being used to self-medicate without physician supervision, or were so poorly formulated these products posed a threat to public health requiring them to be banned. What is clearly needed is balanced regulation to ensure that kratom products purchased by consumers are pure and unadulterated, in other words meeting the same types of standards that apply to other food products, and even bottled water. Steps toward such standards were taken in states that passed their own versions of kratom consumer protection act laws. Ultimately, the Food and Drug Administratio...

Is Kratom an Opiate? Kratom Alkaloids and Effects

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  Concentration percentages given come from different studies of alkaloid concentrations in Mitragyna speciosa ( Kratom ) leaf. Some of the alkaloids given in this list still need to be studied more specifically in order to determine their potential activity. Mitragyna speciosa (kratom) Alkaloids Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial, possible psychedelic (5-HT2A) antagonist. Mitragynine is the primary alkaloid in kratom, and is believed to be responsible for the majority of its effects. Roughly 66% of total alkaloid content found in Kratom leaf. Paynantheine: Indole alkaloid. Appears to be a smooth muscle relaxer, but there is limited research available and more needs to be done. 8.6% to 9% of total alkaloid contents in Kratom leaf. Second most abundant alkaloid. Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. < 1%" of total a...

Paid Kratom User Study - National Institute of Health

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Use kratom regularly? You could qualify for a fully remote research study at NIDA. Complete the study on your smartphone Up to $170 provided for participation Make an impact on kratom science. See If you qualify about the KEMA Study. About The KEMA Study NIH is conducting a new study on kratom entitled “Real-world momentary assessment of kratom use accompanied by product assays: A natural history study toward an interdisciplinary characterization of kratom use and pharmacology”! That is a long name, so we typically refer to it as our Kratom Ecological Momentary Assessment (KEMA) study. Ecological momentary assessment is a method for collecting information from study participants in real time, in the moment, wherever they are. This is done using a secure app on a smartphone. This way, we can understand where, when, how, and why kratom is being used in people’s everyday lives. This Research Study is about kratom use in people’s everyday lives. Our goals are to understand krat...