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Showing posts with the label 7hydroxymitragynine

Therapeutic potential and liability of the Mitragyna speciosa (kratom) alkaloids

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  Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine Abstract Kratom, derived from the plant Mitragyna speciosa, is receiving increased attention as an alternative to traditional opi- ates and as a replacement therapy for opiate dependence.  Mitragynine (MG) and 7-hydroxymitragynine (7-HMG)  are major psychoactive constituents of kratom. While MG and 7-HMG share behavioral and analgesic properties with mor- phine, their reinforcing effects have not been examined to date. 7-HMG, but not MG, substituted for morphine self- administration in a dose-dependent manner in the rat self-administration paradigm. Following the substitution proce- dure, re-assessment of morphine self-administration revealed a significant increase following 7-HMG and a significant decrease following MG substitution. In a separate cohort, 7-HMG, but not MG, engendered and maintained intrave- nous self-administration in a dose-depen...

10 Reasons Why People Are Switching from Powder to Kratom Capsules

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  A survey done in 2019 tallied that 15,600,244 people use kratom in the US, with 1,950 metric tons imported to the country every month. So, what makes kratom special? Well, it’s being employed as a stimulant, mood enhancer, and pain-relieving agent. It comes from the Mitrogyna speciosa tree. The leaves are harvested after maturation and then processed into  powders ,  capsules ,  extracts , or the raw leaves boiled to  make tea . Long ago, traders wanted to preserve the leaves for export because they rot fast. They found that grinding them to a fine powder was the only way to preserve the chemical content. Users accustomed to the  ‘toss n’ wash’ technique  with the powder now find it better to consume kratom capsules. It, therefore, all comes down to personal preference and various other factors. Why People Are Switching to Kratom Powder 1. Capsules are Better Tolerated Kratom ingested in powder form has a bitter, unpleasant taste to many users. On th...

Does Kratom Case Weight Gain? - Kratom Effects

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   Kratom  has become a very popular herb among individuals seeking natural alternatives to painkillers and anxiolytics. The plant is used for many reasons, including pain relief, anxiety relief, to increase energy and, especially, to get off synthetic opioids or ease their  withdrawal symptoms . But, like any other herb, kratom doesn’t come without side effects. People who use kratom regularly have reported some unpleasant effects, such as nausea, stomach upset and constipation. Typically, these side effects are not serious and will disappear after a few days since you stop using kratom. On the other hand, some people have experienced other effects, including  weight loss . However,  there are also users who report that kratom may be making them gain weight . But, is this possible? Does kratom cause weight gain? We’ll explore this subject in this article. Why Do We Gain Weight? Every person is different, and  there are many factors that can cause weig...