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What is kratom? The science behind Mitragyna's strange leaves

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  Long used as a painkiller overseas, the plant has gained in popularity among American opioid addicts trying to get clean. Meanwhile, researchers are making headway as U.S. regulators consider cracking down. Step into the forest around a rural Malaysian village, pluck the  red ,  green  or  white-veined  leaves off a kratom tree, and start chewing. At a small dose, the leaves will act as a stimulant helpful for getting through long hours of hard labor. At a much higher dose, they may cause nausea, vomiting and indigestion, followed by euphoria. At a dose somewhere in between, kratom becomes a highly effective painkiller that can take the edge off after a day’s work. It also can stave off the symptoms of heroin withdrawal. The leaves of Mitragyna speciosa, kratom’s Latin name, have been used for centuries throughout Southeast Asia for all of the aforementioned properties. The plants grow wild in Malaysia, Thailand and Indonesia, with related species of the ...

Respiratory effects of oral mitragynine and oxycodone

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  Kratom derives from Mitragyna speciosa (Korth.), a tropical tree in the genus Mitragyna (Rubiaceae) that also includes the coffee tree. Kratom leaf powders, tea-like decoctions, and  commercial extracts  are taken orally, primarily for health and well-being by millions of people globally. Others take kratom to eliminate opioid use for analgesia and manage  opioid withdrawal  and use disorder. There is debate over the possible respiratory depressant overdose risk of the primary active alkaloid, mitragynine, a partial μ-opioid receptor agonist, that does not signal through ß-arrestin, the primary opioid respiratory depressant pathway. Objectives Compare the respiratory effects of oral mitragynine to oral oxycodone in rats with the study design previously published by US Food and Drug Administration (FDA) scientists for evaluating the respiratory effects of opioids (Xu et al., Toxicol Rep 7:188–197, 2020). Methods Blood gases, observable signs, and mitragynine ph...

10 Reasons Why People Are Switching from Powder to Kratom Capsules

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  A survey done in 2019 tallied that 15,600,244 people use kratom in the US, with 1,950 metric tons imported to the country every month. So, what makes kratom special? Well, it’s being employed as a stimulant, mood enhancer, and pain-relieving agent. It comes from the Mitrogyna speciosa tree. The leaves are harvested after maturation and then processed into  powders ,  capsules ,  extracts , or the raw leaves boiled to  make tea . Long ago, traders wanted to preserve the leaves for export because they rot fast. They found that grinding them to a fine powder was the only way to preserve the chemical content. Users accustomed to the  ‘toss n’ wash’ technique  with the powder now find it better to consume kratom capsules. It, therefore, all comes down to personal preference and various other factors. Why People Are Switching to Kratom Powder 1. Capsules are Better Tolerated Kratom ingested in powder form has a bitter, unpleasant taste to many users. On th...

What is MIT 45 Kratom Extracts and their Top 5 Products

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  What is MIT 45 Kratom Extracts and their Top 5 Products After the pandemic, humans have understood the importance of leading a healthy life. When the situation boiled down to the survival of the fittest, people realized what harm the chemical products had been causing to their bodies. Since then, many have started resorting to natural solutions to their health issues. However, one should also understand that though organic products are more beneficial than synthetic ones, all of them do not share similar potency. For example, cannabis (CBD) works better than ginger, whereas Kratom extract is more potent than CBD. -  Kratom vs. CBD  – Differences, similarities and comparison chart Kratom Similarly, the potency differs even among products of the same origin. Such as, Maeng da Kratom liquid works better than Maeng da  Kratom powder  because of the difference in the  alkaloid  content. You should also note that every human body reacts differently to the ...

Does kratom cause liver damage? Kratom Liver toxicity

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  Kratom is a popular herbal supplement widely consumed and believed to be safe by many. This assumption is based on the fact that nobody regulates production, distribution, and use. However, for this same reason, it could be very unsafe, and some studies hint at its possible side effects. Due to its lack of regulation, a few US states have banned kratom ( Kratom Legality Map and information . States, Cities and Counties where Kratom products are prohibited). One of the major controversies surrounding this substance is kratom-induced liver injury. Drug-induced liver injury is a commonly researched topic, and studies have linked excessive kratom use with acute liver injury. Furthermore, the Food and Drug Administration (FDA) does not recommend or approve kratom for medicinal uses. The Drug Enforcement Administration (DEA) also outrightly classifies kratom as a ‘Drug and Chemical of Concern.’ Before exploring further, it is crucial to examine if kratom is addictive to give rise to le...

Remarkable Herbs Kratom - Product Review

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  Remarkable Herbs  is one of the biggest names on the smoke shop circuit. You would be hard-pressed to find a filling station or head shop that hasn’t carried the pouches with the tropical design. This wholesale brand has placement in thousands of locations. Over the last 5+ years, vendors have had to deal with everything from slanted media attention and a potential kratom ban to DEA seizures and FDA kratom recalls. Remarkable Herbs has weathered all of this chaos with aplomb and come out the other end with a renewed commitment to excellence. Read on to get the skinny on how this supplier has succeeded and why it’s worthy of your patronage. Rating: 4 Remarkable Herbs has built up a solid reputation over the years. It has AKA certification and its selection of herbs can be found in shops nationwide. About the Company This North American wholesale distributor may be the oldest kratom vendor on the market. Remarkable Herbs was first established back in 2001. The company speciali...

Different Kratom Strains & How Did They Get Their Names?

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  Decisions, decisions … It seems like every consumer product comes in dozens of different varieties, enough to give the most decisive person analysis paralysis. With hundreds of years of use and development behind it, Kratom is no exception. A quick visit to  your favorite Kratom  vendor will leave you astounded by the sheer variety of choices available. Strange, exotic named Kratom products greet you everywhere you look. That’s not a marketing stunt, by the way; it’s a natural byproduct of the plant’s origin. Since the plant is found in Southeast Asia, its nomenclature is heavily influenced by that location. We are going to take a closer look at the different  Kratom strains , and how they get their names. With Kratom, you have two major decisions to make when you buy – the color, and the strain. While all Kratom comes from the plant Mitragyna speciosa, trees grown in different regions have evolved with different genetic profiles. This has resulted in different alk...