Kratom & Tramadol: A Dangerous Combination
Kratom & Tramadol: A Dangerous Combination If you enjoy kratom , it’s in your best interest to know how it interacts with opioid medications such as tramadol. Kratom is an all-natural substance, but it interacts with the same receptors as pharmaceutical opioids, which can have profound implications. This guide will fill you in on everything you need to know about mixing kratom and tramadol. Does Kratom Interact With Tramadol? Yes, kratom and tramadol are very likely to interact — potentially leading to life-threatening side effects. Firstly, tramadol and kratom both activate opioid receptors, decreasing the amount needed to overdose. Kratom and tramadol also compete for liver metabolism. Taking them together can slow the elimination of both substances, leading to a higher chance of side effects. This issue is compounded with repeated doses. The metabolization of kratom and tramadol is primarily through the CYP2D6 enzyme. Mixing tramadol and kratom leads to increased blood plas...